Primary immunodeficiency diseases (PIDD) is a disease in which the development, maturation, and activation of various types of immune cells in the body are out of control, causing the child’s immune cells to fail in their duty to fight foreign germs, often causing infections. In the United States, the PIDD Foundation has proposed ten warning signs to suspect PIDD, including: 1. eight or more new ear infections in a year 2. two or more severe sinus infections in a year 3. two or more months of ineffective antibiotics 4. two or more bacterial pneumonia infections in a year 5. no weight gain or abnormal weight in infants 6. recurrence of deep Skin or organ abscesses 7, persistent thrush after one year of age 8, the need for intravenous antibiotics to clear the infection 9, more than two deep infections 10, family history of primary immunodeficiency Some specific PIDD, but also often in adulthood, adults with innate immunodeficiency disease, there are six warning signs. These include: 1. four or more infections requiring antibiotic therapy within a year (otitis media, sinusitis, bronchitis, pneumonia); 2. recurrent infections or infections requiring extended antibiotic therapy; 3. two or more serious bacterial infections (osteomyelitis, meningitis, sepsis, cellulitis); 4. two or more X-ray confirmed pneumonias within three years; 5. unusual location or strain of infection; 6, family history of PIDD.