Masturbation does not cause nephritis, masturbation can lead to kidney deficiency, premature ejaculation, impotence sexual dysfunction. Kidney deficiency is a term used in Chinese medicine, not a Western medicine disease of the kidney organs. The actual nephritis is a group of nephritis syndrome with clinical manifestations of hematuria, proteinuria, edema, hypertension, nephritis is divided into acute nephritis and chronic nephritis, acute nephritis without special treatment, bed rest and symptomatic treatment treatment, most patients can be self-healing, a few patients turned into chronic nephritis. The chronic nephritis is more aggressive control of blood pressure reduction, proteinuria positive to improve the relevant examination, with kidney biopsy indications, kidney biopsy is recommended to clarify the type of pathology, guide the treatment, determine the prognosis. The chronic nephritis is a chronic progressive disease until the end stage of renal failure, that is, the uremic phase. Once the symptoms of uremia appear, such as symptoms of digestive system, like nausea, vomiting, loss of appetite, or even gastrointestinal bleeding, or the manifestations of heart failure such as chest tightness, shortness of breath, dyspnea, the manifestations of uremic encephalopathy, like mental confusion, hallucinations, coma, severe anemia, anemia difficult to correct, severe metabolic acidosis infection, this is the time to carry out renal replacement therapy, such as hemodialysis or peritoneal dialysis treatment.