The causes of headache are complex, both intracranial and extracranial; both local and systemic; both organic and functional. The main factors commonly associated with headache are: 1. Vascular headache: vascular dilation or spasm: extracranial arterial dilation is most common in migraine and frontal arteritis. In the case of acute and chronic intracranial and extracranial inflammation, pathogens and their toxins can cause vasodilatory headache; metabolic diseases, toxic diseases, traumatic brain injury, after epileptic seizures, hypertensive encephalopathy, and large amounts of cerebral vasodilators can cause vasodilatory headache. Vascular traction, compression or stretching displacement: intracranial occupying diseases; increased intracranial pressure caused by acute meningitis and encephalitis, toxic encephalopathy, cerebral edema, hydrocephalus, venous sinus thrombosis, cerebral tumor or cysticercosis caused by compression and blockage of cerebrospinal fluid circulation; also seen in the headache caused by more cerebrospinal fluid outflow after lumbar puncture and lumbar anesthesia, and decreased intracranial pressure, resulting in intracranial venous sinus and venous dilation. 2.Headache caused by stimulation of meninges: headache caused by acute and chronic inflammatory exudates in the skull (such as peritonitis, etc.), or blood from hemorrhagic diseases (such as subarachnoid hemorrhage, etc.) stimulating the meninges, or cerebral edema causing the meninges and blood vessels to be stretched. 3.Nerve stimulation: inflammation and compression and displacement of cerebral nerve (such as trigeminal nerve, etc.) and cervical nerve can cause corresponding neuralgia. 4.Headache caused by spasmodic contraction of head and neck muscles: Head and neck muscle tension, inflammation, local mass, chronic abscess and other neck diseases reflexively cause spasmodic and persistent contraction of cervical muscles, resulting in headache. For example, headache caused by cervical spine lesion is also called muscle contraction headache. 5.Radiation or involvement headache of organs near the head: It is common that lesions or inflammation in the eyes, ears, nose, sinuses, teeth and other parts can spread or reflect to the head and produce headache. 6.Functional headache: It is often classified as headache caused by other reasons, and there are common psychogenic headache, mainly due to mental or emotional headache caused by the cause of insomnia, neurosis headache, somatization disorder, hysteria or depression, etc. Different causes are treated differently, and targeted individualized treatment should be taken.