Delusions of grandeur is one of the symptoms of mental disorders. As the name implies, patients have confused thinking and often think that someone is harming them or that they will receive harm at any time, which can be accompanied by typical manifestations such as depressed mood, misperceptions, pessimism and disappointment, etc. Because the disease has the characteristics of continuous attacks, it is difficult to cure, so there is no specific clinical cure program. But patients do not need to worry too much, usually under the guidance of doctors, timely medication, psychotherapy to intervene in the condition, while the patient with a high degree of cooperation, to a certain extent can achieve the effect of cure: a. Medication: 1. Anti-psychotic drugs: because patients are in a long-term fear of misperceptions for others, the pathological thinking will become more and more serious, in order to avoid depression, suicide and other In order to avoid depression, suicide and other consequences, patients need to seek medical advice in a timely manner and take drugs such as risperidone, paliperidone and amisulpride to relieve tension and fear; 2, sedative drugs: patients with delusions of grandeur tend to fluctuate in mood, and in the case of irritability and irritability, may cause harm to themselves as well as others, so they should be treated by a professional doctor for sedation, and clinically more drugs such as phenobarbital. Second, psychotherapy: patients in the drug treatment, but also need to go to the hospital for psychotherapy, so as to achieve the effect of assisting the recovery of the disease. In general, psychotherapy mainly involves doctors providing comfort, understanding, and companionship to patients from their subjective emotions, and instructing their family members to properly guide the patients’ emotions and not to exert pressure, so as to eventually create a safe and comfortable environment for patients and reduce psychological anxiety and paranoia. Although the above-mentioned approaches have positive effects on patients’ recovery, there are individual differences in the specific treatment effects, depending on the patients’ own disease development and psychological acceptance, so not all patients can achieve a complete cure. In addition, if the patient is suffering from organic diseases, such as Alzheimer’s disease, he or she needs to be treated for the primary disease.