Pulselessness clinically mainly refers to the absence or diminished pulsation of the radial artery in the hand, which cannot be palpated. Patients may show symptoms of upper limb ischemia, such as upper limb weakness, limb pain, decreased skin temperature, pale and dry complexion, and end limb nutritional disorders. Patients often feel cold in the limbs and wear more clothes than others without feeling warm. In addition to not being able to feel the pulse during examination, the blood pressure of the affected limb is also lower than the blood pressure of the opposite normal upper limb. In severe cases, patients have cold skin, cyanosis and necrosis of the finger ends. It is a clinical manifestation after narrowing or occlusion of blood vessels in the upper extremity due to aortitis or atherosclerosis. If the stenosis or occlusion is located at the subclavian artery proximal to the vertebral artery, it is also called subclavian artery steal syndrome. In addition to ischemic symptoms in the upper extremity, these patients often present with cerebral ischemic manifestations such as dizziness and blurred vision. This is because the narrowed distal limb steals blood from the brain through the vertebral artery, thus making the blood supply to the brain insufficient. The greatest danger for this kind of patients is the secondary injury caused by fainting after sudden cerebral ischemia cranio-cerebral bump and other accidental injuries, some of which are fatal blows. For example, if you are riding a bicycle on the highway and your brain suddenly faints from ischemia, because it is relatively sudden, the driver is often negligent and it may lead to a car accident, so you should be diagnosed and treated as early as possible. The diagnosis of this type of patients is not difficult, if the patient presents with the above symptoms, the diagnosis can be easily confirmed by ultrasound, CTA or DSA and other imaging examinations. For treatment, the first step is to control the primary disease. Many patients with pulselessness, especially young female patients, are often caused by polyarteritis. If the disease is active, we should first actively treat the aortitis and then perform vascular opening treatment after the disease is stabilized. After the condition is clearly defined, vascular opening treatment should be performed as soon as possible to restore adequate blood supply to the upper limbs and brain. The traditional treatment method is surgery, which requires open arterial endothelial stripping plus autologous vein patch repair, vascular bypass or artificial vessel transplantation, etc., which is traumatic, costly and has many complications. Drug therapy is generally ineffective for this type of disease. With the development of interventional techniques, these diseases can be treated well and most patients can be completely cured. The problem can be solved in some people by dilating the narrowed vessel with a balloon. If the lumen of the stenosed vessel is not effectively restored after dilation, it can be solved by stent placement, and usually the problems of all patients can be solved by these two approaches. The advantages of interventional treatment are that it is less invasive, safer, less expensive, and most of all, it can cure the disease quickly.