1.Lack of sleep, difficult to sleep, wake up early; 2.Headache, stomach pain, neck and back pain and other physical discomfort; 3.Slow speech and action; 4.Lack of appetite, weight loss or weight gain; 5.Lack of interest in things, not happy; 6.Lack of energy, easily fatigued; 7.Self-perception of useless, no hope; 8.Thought is not focused, can not make up their minds; 9.Often think of death or attempt suicide.