Patient: 5 months pregnant in 2007, nose bleeding, bleeding spots on body, hematuria. Platelets were 0 Had used 1 gram of methylprednisolone shock therapy several times, now platelets are normal, but urine protein has increased. Now using cyclophosphamide four times, once every ten days. There is a slight improvement. Please tell me if you are now developing lupus nephritis Guangzhou First People’s Hospital Rheumatology and Immunology Cai Xiaoyan: According to the information you provided, you are now indeed progressing to lupus nephritis. Hormones and cyclophosphamide are the most classic regimen for lupus nephritis. Cyclophosphamide is available once every two weeks, once a month and once every other day, each with a different dosage each time. Observe the efficacy and pay attention to monitoring side effects. Patient: Thank you, Dr. Cai. Is lupus nephritis treatable? Is it possible to return to normal or not? How long can life be prolonged? Cai Xiaoyan, Rheumatology and Immunology, Guangzhou First People’s Hospital: Lupus nephritis can be divided into six types according to the pathological changes of the kidney, among which type I and type II are mild, type III, IV and V are heavier, and type VI is end-stage nephropathy. Lupus nephritis is mild or severe, but except for type VI lupus nephritis, which is an advanced lesion that cannot be recovered, most lupus nephritis can be controlled with proper treatment, and some of them can be cured with complete remission. Your condition is just developing to kidney damage, and timely treatment has a full chance to return to normal. At present, the treatment of lupus erythematosus is much more advanced than before, and the survival rate is greatly extended. Although this disease can be life-threatening when it is critical, but with good treatment and control, life can be the same as ordinary people, so don’t worry too much.