The child, female, 10 years old, presented to our clinic on November 20, 2015 with a skin rash with itching for 5 days. The child had a skin rash and itching for no apparent reason 5 days ago, and had been treated for “urticaria” and “erythema multiforme” in the dermatology departments of two tertiary care hospitals, and treated with ceftizoxime plus dexamethasone, Pulverizine, and cetirizine, but the effect was not controlled. The rash worsened and was accompanied by abdominal pain. 2 days ago, he was treated at a health care center and was examined and found to have increased blood WBC and neutrophils. On physical examination, he saw: edematous erythema on the skin of the whole body, especially on the head and face of the limbs, without fever. His pulse was stringent and his tongue was red and greasy. Blood WBC 12,000, neutral 85%, urine occult blood ++ (no discomfort in urine and pubic area, not menstruating), consider: 1, urticaria (infectious); 2, acute nephritis. Chinese medicine considered “addiction rash (evil heat stagnation lung), treatment, Western medicine to give cefixime, prednisone (4 tablets), ketotifen, traditional Chinese medicine to give mahogany stone Gan Tang plus anti-feng cicada, treatment after a symptom improvement, itching disappeared, the rash slightly reduced, the next day to reduce the dosage of prednisone to 2 tablets, traditional Chinese medicine changed to eliminate wind, treatment after 2 days the rash completely subsided, but the patient appeared double lower limbs edema with pain The rash completely disappeared after 2 days of treatment, but the patient developed edema with pain in both lower extremities, and the pain was relieved after his parents soaked him in warm salt water.