Headache is a common symptom of depression, with the characteristics of no fixed pain location, easy to be affected by emotion and poor effect of painkillers: 1. No fixed pain location: more attacks in the morning and afternoon, no fixed pain location, most patients complain of pain in the whole head or scalp; 2. The symptoms of headache will also be strengthened or weakened accordingly; 3. Poor effect of painkillers: Since headache is caused by psychological factors, patients’ head examination is generally normal and conventional painkillers such as aspirin have no therapeutic effect on pain. In addition, the treatment of depression headache is mainly taking antidepressant drugs, and the headache will be relieved when the depression is relieved. Therefore, the patient should strictly follow the doctor’s instruction to use the medication, even if the headache has been eliminated, the medication should not be reduced and stopped without authorization, and the treatment must be carried out in full amount and in full course to avoid the relapse of the disease; if there is any adverse reaction, the patient should contact the doctor in time to deal with it.