Some of the initial manifestations of depression have similarities with other diseases and should be distinguished from organic diseases, as follows: 1. hypothyroidism: manifested as dullness, not wanting to move, not wanting to eat, fatigue, fatigue, slow reaction, very similar to depression, can be identified by checking thyroid function; 2. internal diseases: such as anemia, patients do not want to move, do not want to eat, do not want to talk, poor mental state, depression The patient can be identified by taking blood tests for routine blood tests, etc.; 3. Other diseases: Patients who take hormone drugs for a long time may also show similar manifestations of depression. Therefore, patients with first diagnosis of depression must be asked patiently to exclude organic diseases and avoid misdiagnosis.