Syphilis is a chronic, systemic, classic sexually transmitted disease caused by the pale spirochete, which can invade all organs of the body and produce a variety of signs and symptoms. On the other hand, syphilis may remain asymptomatic for many years and be latent. It can be divided into post-acquired syphilis and fetal syphilis (congenital fetal syphilis). Acquired syphilis is further divided into early and late syphilis. Early syphilis lasts less than 2 years and includes stage 1, stage 2 and early latent syphilis. Late syphilis has a duration of more than 2 years and includes late benign syphilis, cardiovascular and neurological syphilis, and late latent syphilis. Fetal syphilis is further divided into early (onset within 2 years of birth) and late (onset after 2 years of birth) fetal syphilis. Syphilis is mainly transmitted through sexual intercourse, but can also be transmitted to the next generation through the placenta and occur congenital syphilis. I. General principles 1, early detection, timely treatment. Early syphilis by adequate and sufficient treatment, about 90% of early patients can achieve the purpose of eradication, and the earlier the effect of treatment, the better. 2, the dose is sufficient, the course of treatment rules. Irregular treatment can increase recurrence and promote the early occurrence of late damage. 3.After treatment, we should follow up for enough time. 4, all infectious sources and sexual partners should be examined and treated at the same time. Second, the purpose and requirements of treatment 1, early syphilis. Require the disappearance of symptoms, eliminate infectiousness as soon as possible, strive for serum negative, prevent recurrence and occurrence of late syphilis. 2.Late stage skin, mucous membrane, bone and joint syphilis requires disappearance of symptoms, prevention of new damage, recovery of functional disorders to a certain extent, prevention of cardiovascular and neurological syphilis, not necessarily requiring seronegative transformation. 3.Early fetal syphilis. Require the disappearance of symptoms, and strive for serum negative. When the child’s visceral damage is more and more serious, the first step is to save the child’s life and to carry out treatment carefully to avoid serious Jihai reactions. 4.Late stage fetal syphilis. It is required to heal the damage and prevent the occurrence of new damage, not necessarily requiring seronegative transformation. 5.Lurking virus. Mainly for the prevention of various relapses, to prevent the progression of the disease and the occurrence of late syphilis, early latent syphilis to strive for seronegative, while the late latent syphilis does not require seronegative. 6, cardiovascular syphilis, neurosyphilis and various visceral syphilis. Before treatment with penicillin, it is best to combine the treatment with the relevant specialties and carefully carry out anti-syphilis treatment, and avoid the rapid treatment with a large number of anti-syphilis drugs in a short period of time to avoid serious dysfunction of important organs caused by scar contraction.