Superbugs are bacteria that are extensively drug-resistant and extremely difficult to kill with existing drugs. The “superbugs” that have been reported in various media recently refer to Enterobacteriaceae named “NDM-Ⅰproducing bacteria”, which can produce metallo-beta-lactamase, making them resistant to almost all beta-lactam antibacterial drugs. They are resistant to carbapenems, aminoglycosides, and quinolones; they were first discovered in India and have since been reported in the United States, Canada, Japan, South Korea, Australia, Belgium, and Hong Kong and inland areas of China. Superbugs with widespread resistance are often encountered in our clinical work, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Staphylococcus aureus (VRSA), and vancomycin-resistant Enterococcus (VRE), etc. They can fall into this category. The pathogenicity of these bacteria is not increased, and the clinical manifestations of the diseases caused are not fundamentally different from those of sensitive bacteria. It mainly infects critically ill patients, patients admitted to intensive care units, long-term application of antibacterial drugs, intubation and mechanical ventilation are susceptible factors, and can cause urinary tract infections, wound infections, ventilator-associated pneumonia, catheter infections, etc. These bacteria make clinical use of drugs difficult due to their extensive drug resistance, and the cure rate of infection is low. The available antibacterial drugs are tigecycline, polymyxin, linezolid, etc. For NDM-Ⅰproducing bacteria, the sensitivity rate of tigecycline is 56%~67% and the sensitivity rate of polymyxin is 89%~100% in in vitro experiments, and the specific medication is selected with reference to the drug sensitivity test or in combination with other drugs. The emergence and spread of superbugs is closely related to the widespread use of antibacterial drugs, especially the abuse of antibacterial drugs has contributed to their production and spread. It is now believed that the main mode of transmission of superbugs is by contact. We should start from the following aspects to prevent superbug infections: 1. standardize and carefully use antibacterial drugs, and resolutely eliminate abuse; 2. strict aseptic operating procedures; 3. standardize hand hygiene of medical personnel; 4. strengthen the cleaning and disinfection of key departments, especially the surface of ICU objects; 5. isolate infected people once found to cut off the transmission route.