As the saying goes, medicine is three parts poison. Drugs are a double-edged sword, which may often cause various adverse reactions in the body while treating diseases. Since the kidney is the organ with the richest blood flow in the body and undertakes the main function of removing metabolic waste from the body, it is one of the organs most often damaged by toxins. When suffering from kidney disease or reduced kidney function, drugs are more likely to cause toxic reactions to the kidney or induce immune reactions to aggravate kidney damage, and drug-induced interstitial damage to the kidney tubules is often irreversible. Therefore, drug abuse is extremely harmful to patients with kidney disease. Clinicians must be familiar with the drugs that more often cause kidney damage, and patients with pre-existing kidney disease should also be aware of them and be highly vigilant in using them. Common drugs that cause kidney damage are summarized as follows: 1. Antibiotics: 1. Aminoglycosides: streptomycin, neomycin, gentamicin, kanamycin, butamycin (amikacin); 2. Synthetic penicillin: methylpenicillin, benzylpenicillin; 7, sulfonamides: such as cotrimoxazole; 8, fluoroquinolones: fluoperazine, ciprofloxacin, fluozinic acid (ofloxacin), etc., of which levofloxacin adverse reactions are the least and light. Second, non-steroidal anti-inflammatory drugs: anti-inflammatory pain (indomethacin), futalin (hydroxyclofenac sodium), tolmetin (mebendazole), hydroxyprogesterone (hydroxybutazone), aspirin (para-acetylsalicylic acid), ibuprofen, inflammatory pain Xikang, fenpropathrin, chinolide, naproxen, sulindac, anandamide, etc. Most cold medicines contain some of the above ingredients. Third, analgesics: finasteride, painkillers, compound aspirin APC, paracetamol. Fourth, contrast agents: high concentrations of high doses of iodide can lead to toxic nephropathy, the choice of pancystic glucosamine renal damage is less. V. Cyclosporine A. VI. Osmotic agents: mannitol, low molecular dextran. Seven, certain anti-cancer drugs, azathioprine, allopurinol, cimetidine (ranitidine), etc. Eight, some Chinese medicines: guanmutong (aristolochic acid), cinnabar, andrographis, antibiotics, hosin, fish guts, centipede, thunderbolt, Angong Niuhuang Wan, gentian diarrhea liver soup, etc. Clinicians and patients are urged to fully recognize the importance of drug damage to the urinary system, enhance awareness of prevention, and reduce drug-related kidney damage.