There are many factors that cause depression, mainly including the following: 1, genetic factors: depression is influenced by genetic factors, if there is a history of depression in the family, the chance of others in the family to suffer from depression increases; 2, physiological factors: the occurrence of depression is related to the secretion of certain neurotransmitters in the synaptic gap of the brain, if the secretion of this neurotransmitter is low, it is easy to cause depressive episodes; 3, psychological and social factors: long-term in an unpleasant work, life, family environment, easy to suffer from depression.