The mechanism of headache is mainly caused by the stimulation of nociceptive receptors in the intracranial and extracranial pain-sensitive structures, and headaches caused by fever are generally divided into the following categories: 1. Fever, mainly caused by fever, leads to intracranial and extracranial vasodilatation and stretching of pain-sensitive structures, etc.; 3. Central fever caused by cerebrovascular disease, brain contusion, etc., mainly causes intracranial pain-sensitive structures to be stretched and displaced and vasodilatation causes headache. Intracranial pain-sensitive structures include venous sinuses, dura mater at the base of the skull, proximal internal carotid artery and branches adjacent to Willis ring, and extracranial pain-sensitive structures mainly include skull periosteum, subcutaneous tissues, extracranial arteries, eyes, ears and sinuses. If the patient has severe headache and the cause cannot be clarified, it is recommended to visit a regular hospital for diagnosis and treatment.