A middle-aged man wrote: “Now living is the most painful thing for me, I am not interested in anything, there is no greater sorrow than the death of my heart. Although I am still alive now, my heart has long been dead. I am the most incompetent person, unable to work, unable to adapt to social life. I cannot do my duty to support my parents to the top, and I cannot do my duty to raise and educate my children to the bottom.” One woman said, “No matter how much love people give, it is useless. A warm family and a superior job are not enough to help me resist pain and hopelessness. Even the strongest passionate and romantic love is the same. No passionate and warm love can penetrate my thick shell. The road ahead is not easy to walk, and I believe that my family, friends and parents would rather I disappear from the earth. In any case, there is not much of my original face left, and I think that if I die, it will save everyone’s futile efforts and goodwill.” What should I do if I suffer from depression? I’m afraid no one in this world would choose to be sick if they had a choice. Although there are manifestations of depression such as low mood, lack of interest in doing things, lack of concentration, memory loss, and the whole thinking ability, we still have some options to come out of depression faster. The first is to go to a regular hospital for regular treatment, including medication to receive positive. It is now believed that mood, memory and other psychological phenomena have a biological basis, and just as high blood pressure can be treated with antihypertensive drugs, medication can reduce and eliminate depressed mood, improve sleep and increase vitality relatively quickly and significantly. Of all the means of treating and regulating depressed mood, medication is most definitely effective. The next best thing is to receive psychotherapy. Both cognitive psychotherapy, interpersonal therapy and behavioral therapy are effective for depression. It is important to note that psychotherapy as a specific interpersonal relationship requires a good therapeutic alliance between the therapist and the patient, and requires both parties to believe in and accept a set of theoretical approaches to treatment so that better results may be obtained. Again, the right social support is sought. Both family and friends can provide strong social support, and social isolation can exacerbate depressive expressions. Sharing and communicating emotional and stressful events with friends can make both parties feel closer, but repeated talk and focus on negative events can exacerbate depression. In addition, physical exercise is powerful in improving depression, both in terms of short-term effects and long-term effects. This effect is effective for people of all ages, for both men and women, and is especially pronounced in older adults.