Syphilis is one of the most predominant sexually transmitted diseases, as an infection that is feared by many because it is contagious, because the transmission is mainly sexual, leaving syphilis sufferers to suffer from discrimination and even unable to marry and have children successfully, which is not the end of this nightmare, because after all, most people are curable, so the nightmare will wake up. However, there are so very few syphilis sufferers who are either detected very late or delayed by irregular treatment, and there are also reasons that may be related to immune mechanisms that cause their syphilis serology to persistently not turn negative. This positive serum titer makes it impossible for these patients to live a normal life, but they cannot find the right way to seek medical help, so here is some knowledge of syphilis serology fixation for the patients. Generally speaking, if the serological titers of syphilis do not turn negative and remain at a certain titer for more than six months or even a year after receiving standard treatment, it can be considered as serum fixation. The possibility of neurosyphilis must be excluded before the diagnosis of serofixation can be made. Once the diagnosis of serum fixation is clear, treatment according to the treatment plan of neurosyphilis can be considered once, if the titer is still maintained, it is not recommended to continue treatment, clinical observation and follow-up, regular review of blood syphilis-related indicators can be. Patients with fixed syphilis serum can live normally and are basically not contagious and can have children, but they must be reviewed regularly so that the doctor can give the appropriate treatment plan in time if there are changes in the titer.