The liver is one of the most important organs for drug biotransformation and metabolism. In liver disease, there are different degrees of dysfunction, all kinds of drugs into the liver, often cause liver metabolism overload, internal environment disorders, aggravate liver damage. At present, we often encounter some patients with liver disease in outpatient clinic, always in a large number of drugs, these drugs, the recovery of liver disease does not have much benefit, on the contrary, but rather aggravate the burden on the liver, damage to the metabolism of the liver, and at the same time to the patient to bring about a small economic burden. The following are some commonly used drugs, but in the use of the liver may bring some impact, expect patients with liver disease in the application of attention. 1, sulfonamides, p-aminosalicylic acid, finasteride, iodine-containing contrast agents, neomycin, protein all into hormones and contraceptives, to a certain extent, cause bilirubin metabolism disorders, causing jaundice and transaminase elevation. 2, paracetamol, treatment of schistosomiasis drugs, deworming nitrothiocyanamide, treatment of chronic hepatitis 6-mercaptopurine, azathioprine and phosgene, mitomycin, Zilithromycin, scramgleomycin, actinomycin and other antitumor drugs, as well as Antomin, a large number of nicotinic acid and other lipid-lowering drugs, treatment of dermatologic diseases, aminomethylphenidin, and Chinese medicine pills can be a result of large doses of hepatocellular necrosis and even a small amount can also cause a metamorphic reaction. And transaminase elevation, jaundice, there are also reports of death. 3, rifampicin and isoniazid are commonly used effective anti-tuberculosis drugs, but often cause allergic hepatitis and cholestasis; treatment of diabetes mellitus methylsulfonylurea (D860, extremely easy to cause liver damage. Anti-inflammatory pain can cause severe hepatic necrosis; chlorpromazine, promazine, prochlorperazine, trifluoperazine, etc. can cause cholestatic jaundice. Erythromycin propionate fat cause jaundice, tetracycline caused liver necrosis, triacetin jaundice has been reported. Abuse of hemodynamic vasoconstrictors and antihypertensives, general anesthetics and part of the sedative sleeping drugs, as well as nerve blocking drugs, long-term use of Chinese and Western medicines to activate blood circulation may cause blood circulation dysfunction of the liver, resulting in metabolic dysfunction, causing liver dysfunction and delayed healing. 5, in part of acute hepatitis and chronic active hepatitis, a large number of long-term application of corticosteroids, fat metabolism disorders can occur due to obesity, immune function inhibition and secondary bacterial and mycobacterial infections. Eating well in patients with chronic hepatitis, long-term application of glucose solution drip, can cause fatty liver, resulting in long-term poor liver function. Another example is severe hepatitis with ascites or urinary patients, inappropriate application of potent diuretics, often easy to cause large amounts of water electrolyte loss, induced hepatic coma. It can be seen that hepatitis patients with too much medication, medication, irrational or blind use of drugs, often make a mistake, affect the condition or even aggravate liver damage. Almost all drugs have to be metabolized by the liver, no matter Chinese or Western medicines have the aspect that it can treat the disease, but also have the aspect that it produces side effects. There is still a lack of research on whether more drugs can cause liver damage, so patients with liver disease should pay attention to carefully and reasonably selecting drugs under the guidance of specialists when treating liver disease and its comorbidities or treating concomitant illnesses in self-healing.