Known or suspected pregnancy, vaginal bleeding of undiagnosed cause, known or suspected breast cancer, precancerous or malignant lesions known or suspected to be affected by sex hormones, severe hepatic or renal dysfunction, hematoporphyria, otosclerosis, acute arterial thromboembolic disease (e.g., myocardial infarction, stroke), active deep vein thrombosis, thromboembolic disease (last 6 months), meningioma (progesterone).