Question 1: Doctor, I am a major triple-positive, viral HBVDNA 107, usually check the transaminases are normal, this half-year check three times, are much higher, the doctor said I should antiviral. But I’m afraid to take a lifetime of medication, I’m very stressed, I’m just under thirty, what should I do. With a virus in the liver, it’s like a wooden table with termites inside, which can damage the table. Liver-protecting drugs are like repairing the table, but only repairing the table without killing the ants can’t solve the problem at all, and the table will break down over time (cirrhosis). Anti-viral drugs are the ones that kill ants, but they can’t kill ant eggs. Once you don’t take the medicine, the ants will reproduce again. So is the antiviral “for life”? Patients who do not have cirrhosis of the liver through a long time antiviral, these residual disease “eggs” will be consumed a little, and eventually can not become ants, this time is generally more than 5 years as appropriate. Patients who already have cirrhosis must be safe because of the heavy damage and cannot be repeated, but not for life. Now new drugs that act on all aspects of hepatitis B virus replication are being developed and breakthroughs are being made. In particular, the cure for hepatitis C has allowed more funding to go into the development of a cure for hepatitis B. So about ten years can see the emergence of “root” drugs that can be discontinued, so that instead of oral antiviral drugs, the treatment of patients with cirrhosis is by no means a lifetime! Because we do not have the means to detect whether all the “ant eggs” are dead, it is possible for ants to become active again when the drug is stopped. Therefore, patients who have been taking medication for several years and want to stop should do so under the guidance of a doctor. If the virus is active again, it will not become drug-resistant and liver failure if it is detected in time. Besides, the side effects of antiviral drugs are very few, you can consult around the patient will know. Answer: The patient’s condition requires antiviral therapy (see my article – Antiviral Series 1 for specific reasons), and oral antiviral drugs are the appropriate choice. Summarize, have confidence, monitor often, and refer to your doctor’s opinion.