Angioblastoma is a benign mesenchymal tumor, but there are very few cases that exhibit malignant tumor characteristics. In clinical practice, angioblastoma is easily misdiagnosed as hemangioma or vascular malformation, and cases occurring in the subxiphoid area are easily misdiagnosed as nail infection or other tumors. The cause of hemangioblastoma is still not clear, but most of them are thought to be benign tumors formed by the abnormal proliferation of vascular bulbs under the action of certain triggering factors, and the vascular bulbs are more frequently distributed under the skin of fingers, palms, toes, and soles; under the action of trauma and other triggering factors, the abnormal proliferation of cells develops into hemangioblastoma, which is most common in the end of limbs, especially under the nail. Most of the hemangioblastomas are small single tumors with a diameter of less than 1 cm, while those occurring in other parts of the body other than the nail can reach a diameter of several centimeters, and a few cases can be seen clinically as multiple hemangioblastomas. Small purple or pink spots under the nail can be seen locally. In conclusion, hemangioblastoma is a benign soft tissue tumor, but some of the tumor cells have certain malignant cell division characteristics, and further pathological studies on some cases with malignant cell division characteristics are worthy of attention; most of the hemangioblastomas are solitary and can occur in various parts of the body, which can cause certain harm to personal health and affect normal life and work; hemangioblastoma has a certain misdiagnosis rate in the clinic, and the postoperative period is very short. Most hemangioblastic tumors are solitary and can occur in various parts of the body, which are harmful to health and affect normal life and work. Therefore, it is necessary to master the clinical and pathological characteristics of hemangioblastoma, and to make early diagnosis and correct surgical treatment of hemangioblastoma through necessary auxiliary examinations.