Alcoholic Liver Disease? Alcoholic liver disease is a disease of the liver caused by long-term heavy drinking; people who are addicted to alcohol or drink too much can develop alcohol-related health problems, with alcoholic liver disease being the most common organ damage caused by alcohol. Alcoholic liver disease includes fatty liver, alcoholic hepatitis, liver fibrosis, cirrhosis and hepatocellular carcinoma. About 2/3 of alcoholics can develop alcoholic liver disease. After ethanol enters the liver cells, it is oxidized by hepatic ethanol dehydrogenase, catalase and hepatic microsomal ethanol oxidase to form acetaldehyde. Acetaldehyde has obvious toxic effects on hepatocytes, causing obstruction of their metabolism and leading to degeneration and necrosis of hepatocytes. The initial manifestation of fatty liver, continue to drink and then can develop into alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis; Alcoholic cirrhosis in the cause of cirrhosis of the liver than 10.8% in 1999 rose to 24.O% in 2003. Severe alcoholism can induce extensive hepatocellular necrosis or even liver failure; this disease is one of the common liver diseases in China.