Helicobacter pylori-associated disease refers to the associated disease caused by Helicobacter pylori (Hp) infection, which can be treated by eradicating Hp. Helicobacter pylori (Hp) is a gram-negative bacillus, which can be transmitted through the oral-oral and fecal-oral routes, as well as through Hp-contaminated water sources, and the population is generally susceptible to the disease. Patients without contraindications to Hp infection can be treated with quadruple therapy, which is commonly used to eradicate Hp. It is commonly used to be quadruple therapy composed of one proton pump inhibitor + one bismuth agent + two antibiotics, with a course of treatment of 10 to 14 days. Proton pump inhibitor (PPI): inhibit gastric acid, commonly used drugs are omeprazole, lansoprazole, pantoprazole, rabeprazole and so on. Bismuth: commonly used are colloidal bismuth in pectin, etc. It should be noted that it should not be taken with milk, and the stool can be lusterless black-brown during the period of taking the medicine. Antibiotics: commonly used antibiotics are clarithromycin, amoxicillin, levofloxacin, metronidazole, furazolidone and so on. All of the above medications should be used under the supervision of a physician. During the treatment period, attention should be paid to meal portioning, and retest whether Hp is eradicated more than 4 weeks after stopping the drug. It should be noted that due to the adverse reaction of antimicrobial drugs, poor patient compliance, drug-resistant strains and other circumstances, some patients have difficulty in eradicating Hp in the stomach, and need to be differentiated from person to person to formulate the eradication program.