Infantile hemangiomas are clinically common and develop rapidly, but some scholars believe that infantile hemangiomas are somewhat self-limiting and may naturally subside in some children as they grow older.1 However, conservative treatment methods can be adopted for individual fast-growing hemangiomas in the early stage, among which Pingyangmycin injection for hemangiomas is simple and easy to grasp, and its efficacy and complications are small, making it a safer treatment for younger children. It is a safer treatment method for younger children. The principle of action of Pingyangmycin in the treatment of hemangioma is that the drug is injected into the tumor and specifically binds to the intracellular DNA, prompting the oxidation of divalent iron to trivalent iron and generating free radicals, which then acts on DNA, inhibiting the synthesis of cellular DNA and cutting off the DNA chain to interfere with cell division and proliferation, inhibiting the growth of vascular endothelial cells and prompting the degeneration of hemangioma, while Pingyangmycin can lead to local sterile verification, tissue edema, deformation, fragmentation, and degeneration. tissue edema, deformation, fragmentation and fibrosis to achieve the purpose of treating hemangioma.2 Its side effects are mainly fever, skin pigmentation and skin fibrosis which can lead to interstitial pneumonia or pulmonary fibrosis in serious cases.3 If the injection is too shallow and the amount is too large, it can lead to local skin necrosis. Although this method is relatively simple to operate, the following points should be noted during the injection process: ①. Check the child’s condition carefully before the operation, routine examination: blood routine, liver and kidney function, chest X-ray, as well as pay attention to whether the child is combined with other diseases. ②. Use can be in accordance with the instructions, strict configuration of injection solution, the concentration should not be too high, for those with allergies, allergy test can be done, after the injection to observe the child for 1 hour, and then let them leave the hospital. ③. The injection should be done in a multi-point injection method from the center to the edge to ensure that the drug is injected evenly into the tumor, not the extra-tumor tissue, and the injection interval is recommended to be about 3 weeks or even a month, and the interval should not be too short. ④. Since there are reports in the literature that pingyangmycin should be used with caution in newborns, the authors believe that this method should be used after the child is half a year old to treat pediatric hemangiomas that are growing rapidly and not suitable for surgical treatment. In conclusion, Pingyangmycin injection is a relatively simple method for treating hemangioma, easy to be mastered, with less side effects and definite efficacy and fewer complications, and has outstanding advantages compared with other treatment methods, especially for infants and children with hemangioma of the head and face.