Adverse reactions to oral propranolol in the treatment of hemangioma are extremely low, with the following occasional reactions: bradycardia, hypotension, hypoglycemia, bronchospasm, hyperkalemia, etc. Clinically, they manifest as drowsiness, fatigue, dyspnea, wet and cold skin, prolonged capillary filling time, and decreased appetite. Symptoms and prevention of hypoglycemia: Early symptoms include: sweating, tremor, tachycardia, anxiety and hunger, etc. It can be taken 0.5 hours after eating during daytime, and infants <6 weeks should be fed at least once for 4 h, infants 6 weeks to 4 months at least once for 5 h, and infants 4 months at least once for 6 to 8 h. If serious illness occurs while taking the drug, especially illnesses that restrict oral feeding, the drug should be discontinued. Diarrhea: Consider that it may be related to parasympathetic excitation caused by propranolol administration. Diarrhea usually appears 12h after taking the drug, and the child has 3-5 bowel movements daily, which are thin mucus stools. At this time, parents need to be informed to hydrate the child more to prevent dehydration. This symptom will gradually resolve on its own after 2 weeks of medication and no special treatment is needed. The diarrhea symptoms in this group were relieved after 1 to 2 weeks. Sleep changes: They showed increased daytime sleep, excitement and crying before bedtime at night, difficulty in falling asleep, more wakings and shallow sleep. After taking the medication during the day, we asked the parents of the children to play more with the children, reduce the daytime sleep time and create a quiet sleep environment at night, which can effectively improve the sleep disorder of the children. Raynaud's phenomenon: pale hands and feet, decreased skin temperature performance, considered as Raynaud's phenomenon. It disappears after heat preservation treatment, and then continue to take medication and pay attention to the warmth of the child's limbs.