The onset of chronic kidney disease is caused by a combination of factors and its pathogenesis is very complex, but people with the following risk factors have a significantly higher incidence and should be highly alert. Firstly, people with diabetes, hypertension, cardiovascular disease and those with a family history of kidney disease are more likely to get chronic kidney disease, followed by metabolic diseases (obesity, hyperlipidemia, hyperuricemia), long-term use of nephrotoxic drugs (NSAIDs, antimicrobials, etc.), chronic urinary tract infections, urinary tract obstruction, hypercoagulable state, autoimmune diseases (lupus erythematosus, etc.), high protein diet, smoking, excessive alcohol consumption, low Birth weight and age 65 years or older are also susceptible to chronic kidney disease.