1, previous history of affective disorders are prone to the disease; 2, before the emergence of depression, most patients have fidgeting, restlessness and other extrapyramidal reactions; 3, patients often have an indescribable feeling of physical discomfort, a kind of “indefinable sadness”, often manifested as unstable mood, fluctuating anxiety, irritability, lack of interest in things and Depression can occur soon after the drug is used, mostly within a few days to two years after the drug is used, and the greater the amount of drug used, the more likely depression occurs. Pharmacogenic depression has a certain insidious nature, patients should pay attention to it if they have depressive symptoms after using the medication, stop the medication in time, go to the hospital if necessary, and adjust the medication under the guidance of the doctor to alleviate the depressive symptoms and avoid unexpected events.