1.Decreased interest in daily activities, or no interest at all. 2.Do not experience fun in daily work and life. 3.Fatigue, lack of motivation, feeling “lazy”, procrastination, feeling that work efficiency is not as good as before, or feeling that you are no longer competent to do your work; in severe cases, feeling that you have completely lost your ability to work and live. 4.Consciousness of slow brain, sluggishness, indecisiveness in making decisions, forgetfulness, difficulty in maintaining concentration when doing things. 5.Sadness, worry, sadness, easily crying and tears. 6.The brain can’t control thinking about unpleasant things. 7.Sensitivity to external stimuli, fear of movement, worry or fear of bad things happening. 8.Decreased mental capacity, feeling “narrow-minded”, good sulking, vulnerable, and good at taking things to the edge. 9.The experience of affection for other family members is significantly reduced or lost. 10.Reluctant to participate in social activities, reluctant to go out, reluctant to meet people; feel insecure among people, worried about being rejected and abandoned by the group they are in. 11.Feeling that they have become suspicious and sensitive, and that the words and actions of some people seem to be directed at them, and that they often feel hurt and humiliated. 12.Low self-esteem, always feel inferior, see themselves without any merit. 13, look at the future can not see hope, recall the past are failures, the current state of the self comprehensive denial. 14.Poor sleep, can be difficult to fall asleep, sleep, early awakening or lazy in the morning; can also appear “no sleep feeling”. 15, autonomic disorders, such as hot and cold, sweating, pain and numbness in certain parts of the body, panic, suffocation, dizziness, nausea, etc. 16, disease anxiety symptoms: think their physical or mental health is not good; worry or think they have suffered from some kind of incurable disease, etc. 17.Decreased appetite and weight loss. 18.Decrease in sexual desire.