Depression medication works. The main treatment method used for depression is medication, and medication is about single medication as much as possible, sufficient amount, sufficient course, individualized and systematic treatment. The main clinical treatment for depression is the use of 5-hydroxytryptamine reuptake inhibitors, such as paroxetine, sertraline, fluoxetine, citalopram, escitalopram, venlafaxine, duloxetine, mirtazapine and other systemic treatment. The dose of medication taken during the treatment process should reach the highest effective dose to control depressive symptoms, and the duration of treatment should be not less than 3 months in the acute period, and still consolidate the treatment for 4-9 months after the symptoms are effectively controlled, and longer in the later maintenance treatment. So for depression patients medication is very critical and has an important significance for the later development tendency and prognosis of depression.