Penicillin is a common drug for syphilis treatment, generally refers to long-acting penicillin, long-acting penicillin in the current treatment of syphilis is a preferred drug, because the price is cheaper, and the number of applications is less, only need to be injected once a week can, do not need to come to the hospital every day for drug injection. At present, long-acting penicillin is very effective in the treatment of syphilis, so it is the first-line drug in the treatment of syphilis. However, there are some patients who have obvious allergy to penicillin, they can apply penicillin after desensitization treatment, or they can apply ceftriaxone, doxycycline, etc. for alternative treatment.