Advanced stage of liver cancer refers to the development of liver cancer to a certain stage and the emergence of distant metastasis such as lesions metastasizing to lung, bone, adrenal gland, etc., as well as lymphatic metastasis, intrahepatic metastasis, lesions invading surrounding blood vessels and bile ducts, etc. It is the advanced stage of liver cancer. There are many causes of lumbar pain, such as lumbar degenerative disease, lumbar soft tissue disease, kidney stone, etc. However, it is necessary to use CT or magnetic resonance examination to exclude lumbar spine tumor metastasis when liver cancer is accompanied by lumbar pain. If the tumor metastases to the lumbar spine is in advanced stage, besides pain in the corresponding area, the patient will also have pathological fracture, movement and sensory disorders, and paraplegia can occur in severe cases. At this time, besides treating the primary liver tumor, radiotherapy, physical ablation, vertebroplasty and other treatments are feasible according to the condition of metastasis to alleviate the patient’s symptoms and slow down the development of the disease.