(1) Consider the patient’s symptom characteristics, age, physical condition, drug tolerance, and the presence of comorbidities in a comprehensive manner, and individualize the rational use of medication according to the individual. (2) Gradually increase the dose and use the smallest effective amount possible to minimize adverse effects and improve compliance. If the efficacy of small doses is not good, increase to the full dose (upper limit of effective drug) and a long enough course of treatment (>4-6 weeks) according to the adverse effects and tolerance. (3) If the drug is still ineffective, consider changing the drug to another drug of the same type or another drug with a different mechanism of action. (4) As far as possible, a single drug should be used in sufficient quantity and duration of treatment. When the change of medication is ineffective, the combination of two antidepressants with different mechanisms of action can be considered. In general, it is not recommended to use more than two antidepressants in combination. (5) Closely observe the changes in condition and adverse reactions during treatment and deal with them in a timely manner. (6) Psychological stress factors play an important role in the development of this disease, therefore, supplementing psychotherapy with medication is expected to achieve better results. (7) Actively treat other physical diseases, substance dependence, anxiety disorders, etc. that are co-morbid with depression. (8) According to the rules of drug treatment for depressive disorders in foreign countries, SSRIs, SNRIs, and NaSSAs are generally recommended as first-line drugs.