Alkaline phosphatase (ALP or AKP) is an enzyme widely distributed in human liver, bones, intestine, kidney and placenta tissues to be excreted outside the bile via the liver. However, it is not a single enzyme, but a group of isoenzymes. Six isoenzymes, AKP1, AKP2, AKP3, AKP4, AKP5 and AKP6, have been identified. Clinically, the measurement of ALP is mainly used for the diagnosis and differential diagnosis of skeletal, hepatobiliary system diseases, especially for the differential diagnosis of jaundice. For unexplained high ALP serum levels, isoenzymes can be measured to assist in clarifying their organ origin. The reference value of alkaline phosphatase is usually ranging from about 100-145 IU/L. It will vary slightly depending on the different laboratory reagents available at different hospitals. In terms of indicators, alkaline phosphatase 160 IU/L is not serious. However, the actual severity needs to be combined with imaging and other laboratory tests. The most common type is fatty liver, including alcoholic fatty liver and non-alcoholic fatty liver. However, if the increase in alkaline phosphatase is caused by fatty liver, it is not serious and only requires diet control and exercise. Some patients with cirrhosis or liver cancer can also cause increased alkaline phosphatase, which is more serious and should be treated actively for cirrhosis and liver malignancies.