What exactly should I do for headaches? What is the best medicine for a headache? Is surgery necessary for all headaches? These questions are one of the things that many headache patients are concerned about, so today we give you a unified reply: Generally speaking, we treat pain with a comprehensive treatment method, including medication, physical therapy, minimally invasive interventional therapy, neuromodulation techniques and surgery, etc. Sometimes a single treatment method is unable to obtain satisfactory pain relief. For patients with initial pain diagnosis, a clear diagnosis should be made to understand the cause of the pain, and treatment methods that target the cause should be preferred. So here it is necessary for headache patients to remember their headache attack patterns: for example, what conditions produce headaches? How long does the headache last? What treatment has there been? What tests? This will also help to clarify the condition during the consultation. When the cause cannot be completely cured or the pain is not relieved even after the cause is cured, we adopt the principle of “four-step” treatment: first step: non-invasive medication and physical therapy. Second ladder: Minimally invasive interventional therapy, including targeted drug injection, radiofrequency therapy, etc. Third ladder: neuromodulation therapy, including peripheral electrical nerve stimulation, spinal cord electrical stimulation, motor cortex electrical stimulation, etc. The fourth ladder: surgical treatment for chronic pain, including various neurological destructive surgical treatments, etc. Overall, the successful treatment of chronic pain depends on the selection of the right patient, the right method and the right time of treatment. The indications for neurosurgical treatment are strictly controlled, and treatment methods are selected according to the nature of the patient’s pain, underlying disease, survival, quality of life, social security, and affordability.