The etiology of rheumatic fever is due to hemolytic streptococcal infection, and the main diagnostic points include the following; first, fever, which can be low to moderate fever, or high or even ultra-high fever. Second, arthritis, predominantly in large joints such as knee, ankle and wrist joints, which is wandering and multiple. Third, inflammation of the heart, which can present with pericarditis and myocarditis, or even heart failure. Fourth, chorea, showing involuntary movements of the extremities. Fifth, skin changes such as subcutaneous nodules and annular erythema may be seen. Sixth, laboratory tests may show elevated C-reactive protein, increased blood sedimentation, and elevated anti-streptococcal hemolysin.