Scleroderma, also known as systemic sclerosis, has no optimal cure, and the disease is currently incurable, mainly to prevent new skin and organ involvement, and improve existing symptoms. There is no specific drug for systemic sclerosis. Early treatment is mainly to prevent new skin and organ involvement, and in the late stage to improve the existing symptoms, glucocorticosteroids such as prednisone can be used, which is able to reduce the skin edema in the early or acute stage. For combined organ damage, immunosuppressants such as cyclosporine and cyclophosphamide can be used, calcium channel blockers such as nifedipine can be used for Raynaud’s phenomenon, and prostacyclin analogs such as en prostaglandin can be used for ulcers of the fingertips. In addition to the above treatments, oxygen therapy, hydrochlorothiazide, digoxin, etc. can be used in combination with pulmonary hypertension, and dialysis can be used in renal crisis. It is recommended to consult a doctor in time for standardized treatment under the guidance of a doctor when systemic sclerosis is detected.