First of all, have you ever felt dry mouth and dry eyes? I believe that everyone must have had them, but they are short-lived, dry mouth after exercise, dry mouth in the morning; eyes dry after looking at the computer for a long time, dry eyes from conjunctivitis. But many people do not know that there is a disease the most typical symptom is dry mouth and dry eyes. Dry syndrome is an autoimmune disease that mainly involves the exocrine glands. After the salivary and lacrimal glands are damaged, the function decreases and dry mouth and dry eyes appear. Clinical manifestations The disease has an insidious onset, and most patients can hardly tell the definite time of onset, and the clinical manifestations are diverse and the severity of the disease varies greatly. (1) Local manifestation (1) Dry mouth: because salivary glands are destroyed, 70%~80% of patients complain of dry mouth, and in serious cases, because oral mucosa, teeth and tongue are sticky, it is necessary to drink water frequently when speaking, and when eating solid food, it is necessary to send down with water or liquid food, and sometimes it is necessary to get up to drink water at night. Rampant dental caries is one of the characteristics of this disease. It shows that the teeth gradually become black, then small pieces fall off, and finally only the roots are left. ③Parotitis, 50% of patients show intermittent alternating parotid swelling and pain, involving unilateral or bilateral. ④The tongue presents with painful tongue, dry, cracked tongue, and atrophied and smooth tongue papillae. (5) The oral mucosa appears to be ulcerated or secondary to infection. (2) Dry eyes: This is due to damaged lacrimal glands and reduced secretion of mucin, with symptoms such as dry eyes, foreign body sensation, few tears, and in severe cases, painful crying without tears. Some patients have recurrent purulent infections of the eyelid margin, conjunctivitis, keratitis, etc. (3) Other superficial parts such as nose, hard palate, trachea and its branches, digestive tract mucosa, and exocrine glands of vaginal mucosa can be involved, causing less secretion and corresponding symptoms. 2.Systemic manifestations In addition to dry mouth and eyes, patients may also have systemic symptoms such as fatigue and fever. About 2/3 of patients have systemic damage. (1) Skin: The pathological basis of skin lesions is local vasculitis. Rash, Raynaud’s phenomenon, etc. appear. (2) Skeletal muscles: arthralgia is more common. Only a small proportion exhibits joint swelling, but it is mostly non-severe and transient. Destruction of joint structures is not a feature of the disease. (3) Kidney, lung, digestive system and blood system may be affected. When you have prolonged dry eyes and dry mouth that cannot be relieved, you are advised to consult the rheumatology department for early and clear diagnosis and early treatment. The ideal treatment for dry syndrome is not only to relieve the patient’s symptoms of dry mouth and eyes, but also to terminate or suppress the abnormal immune reactions occurring in the patient’s body, protect the patient’s organ functions, and reduce the occurrence of lymphoma. All of these require a detailed and reasonable treatment plan assigned to you by a specialist in rheumatology. There is also a good prognosis for dry syndrome, and most of the conditions can be completely relieved and resume daily life and work with accurate treatment.