The growth of glioblastoma is characterized by infiltrative growth, without obvious boundary with normal brain tissue, mostly not limited to one lobe, and destroying brain tissue in a finger-like manner, with slow growth and long course in benign cases, averaging two years from the appearance of symptoms to the time of consultation, and fast growth and short course in malignant cases, mostly within three months from the appearance of symptoms to the time of consultation, with 70-80% mostly within six months. The treatment for glioma is generally surgery, radiotherapy, chemotherapy, X-knife, gamma knife and other methods. 1.Surgery: Based on the growth characteristics of glioma, it is theoretically impossible to completely remove the tumor, and some tumors growing in important areas such as brain stem cannot be operated at all. 5) to obtain tumor cell kinetic data to provide a basis for finding effective treatment. However, the infiltrative nature of glioblastoma growth theoretically dictates that it is impossible to completely resect the tumor, and even if only a very small amount of tumor cells remain after surgery, they can rapidly grow again and recur. Among the grade I-IV glioblastoma, among which grade I-II is on the benign side, if the growth location is suitable, the surgical effect is relatively satisfactory, but the 2-year recurrence rate still reaches more than 85%; in addition, glioma in the brain stem and other important parts cannot be operated at all. 2.Radiotherapy: Radiotherapy is the routine treatment for almost all types of glioma, but the evaluation of efficacy is different. In addition to medulloblastoma, which is highly sensitive to radiotherapy, and ventricular meningioma, which is moderately sensitive, other types are not sensitive to radiotherapy, and it has been observed that radiotherapy and non-radiotherapy have the same prognosis. In addition, the effect of radiation-induced radiation necrosis on brain function should not be underestimated. 3.X-knife and γ-knife are in the category of radiotherapy: due to the location of the tumor, the size of the tumor (generally limited to less than 3 cm) and the sensitivity of the tumor to radiation, the scope of treatment is limited. At present, it is believed that glioma, especially astrocytic grade III-IV or glioblastoma of malignant nature, is not suitable for X-knife treatment. Chemotherapy: In principle, it is used for malignant tumors, but the efficacy of chemotherapeutic drugs is still uncertain because of the blood-brain barrier and the toxic side effects of the drugs, and the efficiency of BCNU, CCNU, VM-26 and temozolomide is less than 30%.