Depression is mainly a loss of interest, and in the more severe stages, patients experience a weakening of willpower and slow thinking. But depression affects all systems of the body, as it affects the performance of the transmitters in all systems of the body. Affecting the circulatory system, patients may experience panic attacks and chest tightness. One patient always felt panic and chest tightness, but when he went to the hospital for examination, he took a thick pile of examination reports, including ultrasound, electrocardiogram, including cardiogram, and after examination, he found no major problems, but he just felt uncomfortable. In this case, a professional evaluation was later performed and depression was considered. So this kind of panic is mainly caused by the somatization symptoms of depression.