Liver failure, also known as severe hepatitis, is a more serious form of liver damage caused by a variety of etiologies, with a more serious condition and a higher mortality rate. Patients often die from various complications, the common ones being pneumonia, peritonitis, hepatorenal syndrome, hepatic encephalopathy and hemorrhage. However, a small percentage of patients can be cured with active and effective treatment, such as liver failure due to drug-related hepatitis, and some patients may be cured. Liver failure is generally divided into acute liver failure, subacute liver failure, slow plus acute liver failure, and chronic liver failure. Acute liver failure or subacute liver failure is commonly caused by acute hepatitis B, acute hepatitis E, drug-related liver damage, autoimmune hepatitis, and alcohol-related liver damage. Acute liver failure is characterized by liver atrophy, which can appear at the beginning of hepatic encephalopathy, and some patients have hepatic encephalopathy as the first symptom. In subacute liver failure, hepatic encephalopathy and ascites may appear in the later stages. Chronic plus acute liver failure and chronic liver failure are commonly seen in patients with chronic hepatitis B, autoimmune hepatitis, alcoholic liver damage, and cirrhosis of various etiologies. Patients present clinically with high degree of weakness, poor appetite, nausea, vomiting, abdominal distension, yellow urine like strong tea water, heavy yellowing of the skin and eyes, petechiae, petechiae and bleeding spots on the skin mucosa, rhinorrhea, cavernous bleeding and cerebral hemorrhage may occur. The treatment of liver failure is generally based on liver preservation and enzyme reduction, etiological treatment, strengthening nutritional support therapy, and artificial liver and liver transplantation if necessary. Liver failure has a high mortality rate, so if there is liver damage, you should go to the hospital as early as possible for standardized treatment to prevent liver damage from worsening, once it develops into liver failure, it is difficult to save most patients even if they mend their ways.