What is artificial liver therapy? Artificial liver support system is a mechanical, physicochemical and biological device outside the body to remove various harmful substances, replenish essential substances, improve the internal environment, temporarily replace part of the function of the failing liver and create conditions for liver cell regeneration and liver function recovery or wait for the opportunity to perform liver transplantation. Artificial liver support systems are divided into non-biological, biological and hybrid types. The non-biological type of artificial liver has been widely used in clinical practice and has been proven to be effective (II-2). The currently used non-biological artificial liver methods include plasma exchange, blood/plasma perfusion, hemofiltration, plasma bilirubin adsorption, continuous hemodialysis filtration, albumin dialysis, plasma filtration dialysis, MARS, etc. Since the principles of various artificial livers are different, different methods should be selected rationally according to the patient’s specific situation, either singly? alone or in combination. II. Suitable for which patients? Indications (Ⅲ) (1) Patients with early or mid-stage liver failure caused by various causes, with INR between 1.5-2.5 and platelets >50×109/L are appropriate; patients with advanced liver failure can also be treated, but complications are common and treatment risks are high, so clinicians should assess the risks and benefits before making treatment decisions; those who do not meet the diagnostic criteria for liver failure but have rapid disease progression and tendency to liver failure can also Early intervention may be considered. (2) Patients with advanced liver failure waiting for a donor before liver transplantation, rejection after liver transplantation, and non-functional stage of transplanted liver. Relative contraindications (III) (1) Severe active bleeding or diffuse intravascular coagulation; (2) High allergy to blood products or drugs used during treatment, such as plasma, heparin and fisetin; (3) Circulatory failure; (4) Non-stable stage of cardiac and cerebral infarction; (5) Late pregnancy. The complications of artificial liver therapy include bleeding, coagulation, hypotension, secondary infection, allergic reaction, imbalance syndrome, etc. It is necessary to fully evaluate and prevent the occurrence of complications before the artificial liver treatment, and closely observe the complications during and after the artificial liver treatment, with the development of artificial liver technology, the incidence of complications gradually decreases, and once they occur, they can be treated accordingly according to the specific situation.