When it comes to scleroderma, most people think it is a skin disease, which is a misconception. Scleroderma is an immune disease of unknown etiology. Scleroderma is clinically divided into two major groups: those that damage only localized skin are called “limited scleroderma”; those that damage not only the skin but also the bones and internal organs of the body are called “systemic scleroderma”. This section focuses on systemic scleroderma. Modern medicine explains that this disease is based on the pathology of vasculitis, resulting in diffuse fibrotic damage to the skin and internal organs of the body. The pain and danger of this disease is not comparable to that of SLE. The incidence of systemic scleroderma in China is about 1 in 10,000; more women than men, about 10:1; it can develop at any age, but it is more common in adolescents to middle-aged people; more than 95% of patients have Raynaud’s phenomenon as the starting symptom of the disease, in addition, about 5% of late patients develop lung cancer or gynecological tumors. According to the clinical manifestations of systemic scleroderma, it belongs to the pathology of “paralysis” and “skin paralysis gangrene” in Chinese medicine. It is caused by deficiency of endowment, disharmony of camp and body, stagnation of qi and blood, blockage of meridians and channels, and repeated exposure to external evil. The clinical manifestations of systemic scleroderma: 1. Most patients have Raynaud’s phenomenon due to poor blood flow, resulting in pale or purple skin color, coldness, numbness or pain at the ends of the limbs. This ischemic and hypoxic dystrophic Raynaud’s phenomenon is not unique to this disease, in systemic lupus erythematosus, dermatomyositis with polymyositis, dry syndrome and other diseases have a certain percentage of patients. Its characteristics will be described in the pathogenic content. 2. Skin lesions Skin lesions are divided into three stages, one is skin swelling and no indentation (mostly accompanied by Raynaud’s phenomenon). Second, the skin is thickened and hardened like leather, inelastic, the skin is not easily pinched up by the subcutaneous tissue, and has a wax-like luster. Third, the skin becomes thin and smooth, the skin atrophies and clings to the subcutaneous bone surface, the skin lines disappear, the sweat glands atrophy, the hair falls out, and the complexion is interspersed with loss of color. The onset of the disease is first seen on the hands and face, gradually progressing to the neck, arms, chest, abdomen and back, while the lower extremities are less affected and less common. Facial lesions can lead to “mask face”, loss of facial lines, loss of expression, dryness and thinning of the lips, difficulty in opening the mouth, and hawk-like nose tip. Bone and joint lesions: Osteoporosis, joint swelling and pain, commonly in the fingers, wrists, knees, narrowing of the joint space, but no bone fusion. Due to contracture of the skin and tendon fibrosis on the joint surface, joint deformity and tonic fixation often occur. It makes the patient completely lose the ability of self-care. 4. Gastrointestinal lesions Fibrosis of the lower 1/3 of the esophagus, damage to the vagus nerve, obstruction and burning sensation behind the sternum due to stagnant food after swallowing occur in about 60% of cases. Reflux esophagitis also frequently occurs. In addition, the peristalsis of the small intestine slows down, and the intestinal contents often lead to bacterial multiplication due to stagnation, causing a combination of symptoms such as contamination and infection of the small intestine. Then there is the thinning of the colonic muscle layer due to fibrosis, resulting in the formation of diverticula with local protrusion, and a few cases of ulcer perforation. 5, renal lesions The proportion of renal lesions is small, the degree of damage is generally mild, visible proteinuria and tubular, a few patients due to the interlobular artery and into the small artery ischemia when renal failure, is rapidly progressing and death. 6, cardiac lesions Due to myocardial fibrosis and pulmonary hypertension, cardiac arrhythmias and then cardiac insufficiency occur. About 30% of the patients involve the pericardium and a small amount of pericardial effusion appears. Clinical manifestations include palpitations, dyspnea, cyanosis, and edema. On auscultation, a hyperactive second pulmonary artery tone and a presystolic gallop rhythm can be heard. 7. Pulmonary lesions Pulmonary lesions are the early organ of the disease and are the more common symptoms. The main pathological changes are fibrosis of the alveoli, interstitium, and peribronchi. In typical cases, X-rays show increased linear fibrotic streaks, sometimes with cystic changes or a honeycomb pattern. Pulmonary function tests are impaired in the majority of patients, so shortness of breath, cough, and cyanosis occur as a result of more hypoxia during exercise. Based on our experience in clinical observation and treatment, it is believed that the disease occurs mainly due to hyperfunction of the immune system, which stimulates increased antibodies to cells and cellular components and produces immune complexes. Promotes the endocrine system to accelerate the secretion of collagen fibers, which alters the normal metabolic ordering of the body. Thickening and aging of the intima of small arteries leads to obstruction of blood flow and causes loss of nutrients to the perivascular tissues. As a result of the loss of nourishment the tissues and organs also age (fibrosis) and wither. This etiology of the disease, like the immune principle I introduced earlier will be analyzed, this disease must be due to the body itself in the operation of the structure of the problem, it is due to the brain, women’s cells and other Qi Heng of the internal organs of the sensitivity of the over-sensitivity, resulting in the entire body operation of the state of change. So that the stability of the human body model is destroyed, in the slightest external stimulus will make a strong self-injurious reaction. Once this pathological mode of operation is maintained, it is generally difficult to break this vicious circle. Therefore, patients often suffer deeply and helplessly from the fact that this disease cannot be cured. Both autoimmune diseases such as systemic scleroderma and systemic lupus erythematosus can illustrate two things: first, it shows that the same characteristics exist in the pathological features of these autoimmune diseases; second, it shows that the tissues and organs damaged by autoimmune diseases are roughly the same. It is only in the clinical manifestations and forms that they differ. This demonstrates that one pathogenic state analyzed by the immune principle model produces different manifestations in patients. The first choice of modern medicine for the treatment of this disease is hormones, and even cytotoxic agents for the treatment of tumors are also used. The use of hormones may achieve short-term and temporary success, but hormones are pro-aging agents that promote fibrosis (aging) at an alarming rate in tissues, organs, blood vessels, and bones throughout the body, and can cause a significant decrease in the body’s resistance, leading to the patient’s susceptibility to various infections, especially because the pathology of the disease itself It is a disease mainly based on aging (fibrosis) and sclerosis, and the use of hormones is definitely a blind and irresponsible treatment that lacks scientific basis. The immunotherapy of Chinese medicine Qi Heng’s internal organs is to activate blood circulation and remove blood stasis, and activate the meridians. It reaches up to the brain and down to the woman’s cells. Inside to the bone veins, outside to the skin. Activating blood circulation and removing blood stasis is precisely to soften blood vessels and dilate blood vessels, to promote or accelerate the circulation of blood blood oxygen, to make blood blood oxygen flow and fully nourish the whole body, and to remove immune complexes. This can stop the aging of all tissues and organs of the body.