Pregnancy is very important for every pregnant woman, and it is especially important for pregnant women with Hepatitis B. How can a pregnant woman with hepatitis B get through her pregnancy safely? During pregnancy, the burden on the pregnant woman’s liver increases, and fatigue, bleeding, surgery and anesthesia during delivery can aggravate liver damage. In addition, the production of endogenous estrogen increases significantly during pregnancy, and estrogen must be inactivated in the liver, which undoubtedly increases the burden on the liver. For patients with cirrhosis, due to the increase in plasma volume and cardiac output during pregnancy, upper gastrointestinal bleeding is likely to occur, coupled with the fact that the blood of the entire body is in a state of “dilution” during pregnancy, and the level of serum albumin is relatively low, which makes it easy for edema, ascites and peritonitis to occur. The burden of pregnancy on the liver increases with the number of weeks of pregnancy, and the risk of impaired or aggravated liver function increases. Therefore, it is necessary to test the liver function of pregnant women throughout pregnancy, usually every 1 to 2 months, and once abnormalities are detected, it is necessary to consult a specialist to deal with them. In addition, the armed forces liver disease experts reminded, the following points pregnant women should pay attention to: First of all, pay attention to rest and nutrition, especially when hepatitis activity more emphasis on bed rest, eat more high-quality protein diet, such as milk, chicken, fish and lean meat, etc., as well as high-vitamin diet, such as vegetables, fruits and so on. Secondly, it is necessary to use medication under the guidance of a doctor, especially before the 12th week of pregnancy, because the vital organs of the fetus are not yet developed, inappropriate use of medication may cause damage to the fetus. When hepatitis is active, it is necessary to evaluate the condition of the pregnant woman’s liver. If only alanine aminotransferase is elevated and jaundice is not present, vitamin supplements can be given on the basis of rest and nutrition. If there is recurrent nausea and vomiting (to rule out early pregnancy reactions), or if there is jaundice or even ascites, it is necessary to hospitalize the patient in a specialized hospital. Finally, due to the high susceptibility of pregnant patients to hepatitis E virus, mid-late pregnancy infection with hepatitis E virus is prone to develop into severe hepatitis, with a morbidity and mortality rate of 10% to 20%. At the same time, hepatitis E virus infection can contribute to the activity of hepatitis B, which can further aggravate the condition, so it is necessary to pay attention to the prevention of hepatitis E virus infection during pregnancy. Since hepatitis E virus spreads through mouth, especially eating unclean and uncooked shellfish is easy to be infected, so the intake of this kind of food should be avoided. In conclusion, mothers-to-be with hepatitis B should seek more advice from specialists when deciding to become pregnant, pay attention to liver function tests during pregnancy, and go to specialized hospitals once hepatitis activity occurs in order to receive timely treatment.