WHO reports that about 1 in 7 people worldwide will suffer from depression at some point in their lives. 25% of patients with mild depression have had suicidal thoughts, and among those with major depression, the percentage is as high as 75%. In China, 287,000 people die by suicide each year, 63% of those who commit suicide have a mental disorder, and 40% suffer from depression. Depression, the “big black dog”, pulls despair to devour the human consciousness, and fall into the endless swamp of self-blame, behind the laughter in front of people may be the silent torture behind closed doors, the long dark night, in them, even longer. Depression, which is diffuse and paralyzing, has the ability to erase all happiness and hope, and is not a mere psychological disease, but also a real disease with deep biological roots, with complex and numerous causes of its onset. I. Genetic factors The occurrence of depression is closely related to genetic factors, the rate of relatives with the disease is much higher than the general population, and the closer the blood relationship, the higher the incidence rate, 14% of first-degree relatives, 4.8% of second-degree relatives, 3.6% of third-degree relatives. Biochemical factors The imbalance of biochemical system in the body, such as hormones, neurotransmitters, etc.; internal genetic abnormalities, external drugs, work and rest disorders, stress, etc., can also trigger depression. Psycho-social factors The sudden occurrence of major life events, life changes, long-term loneliness, unfamiliarity, low self-esteem and other environments, persistent unpleasant emotional experiences, public opinion pressure. Cultural factors In the West, personal emotional expression is independent of others, but for Chinese people, to a large extent, personal emotions should respond to changes in the environment, holding back everything for the sake of being extremely thorough, self-denial and suppression of emotions because of peace, although depression is suppressed for a while, it is likely to come out unstoppably due to small things. Fifth, other factors abuse and dependence on psychoactive substances, can become a risk factor for depressive disorders, opiates, central stimulants, hallucinogens, alcohol, sedative-hypnotic drugs, etc., especially alcohol abuse. Surveys have found that 50% or more of individuals who drink alcohol on a long-term basis have depressive disorders, and the American comedian Robin? Williams’ depression, most likely caused by alcohol and drug abuse. Somatic diseases can be diagnosed with the help of heaps of instruments and biochemical indicators, but depression is a psychosomatic disease, and its diagnosis and treatment mainly rely on the patient’s complaints and the doctor’s experience. The pathologists found that the activity of neurotransmitter system is changed in the brain of patients, such as: 5-hydroxytryptamine, norepinephrine, dopamine is lower than normal people, antidepressant drugs, can regulate and balance the chemicals in the brain, reduce the symptoms, and even restore the normal life state, but antidepressant drugs must be prescribed by the doctor, follow the doctor’s guidelines. Psychotherapy Psychologists believe that childhood trauma and social pressure lead to depression. Professional psychologists can help patients deal with their emotions, change their way of thinking and find out how to cope with their condition, and the care of family members and friends of depressed patients can also help. In more serious cases, such as suicidal tendencies, the help of psychiatrists and drugs can help shorten the pathological course. 1, relaxed mood, healthy diet Some of the body’s functions can be self-regulation, assist in restoring health, or even self-healing, hormone level imbalance is one of the causes of depression, dietary regulation, the intake of rich vegetables, fruits, regular rest, and drug therapy, help restore the chemical balance of the body. 2, communicate with people, establish self-confidence External pressure affects emotions, and self-closing is not conducive to the condition. Participate in group activities with similar interests, physical exercise, communicate with close friends, or even write a diary to cope with emotions, engage in things that you are good at, and fully believe in yourself.