The coexistence of gastric ulcers and duodenal ulcers is a compound ulcer. These ulcers account for about 5% of patients with ulcer disease. The majority of patients have duodenal ulcer first, which leads to functional pyloric obstruction, which can cause delayed emptying, gastric dilation and stimulation of gastrin secretion, which increases gastric acid secretion and pyloric malfunction causing duodenal fluid to flow back into the stomach, which repeatedly stimulates the stomach and forms gastric ulcer. In patients with compound ulcers, the occurrence of gastric ulcers precedes duodenal ulcers, but the proportion is small. The incidence of bleeding in this disease is high, but the rate of malignant transformation is low. The main symptoms of duodenal ulcer: 1, pain: pain is the prominent symptom of duodenal ulcer disease. The pain is located between the glabella and umbilicus, mostly in the upper abdomen, near either side of the midline, usually on the right side. The extent of pain is often very limited, and patients can often use one or two fingers to clearly point out the area of pain, which is about 2-10 cm in diameter. 2. Acid reflux and flooding: Some patients repeatedly reflux up large amounts of acidic gastric juice that does not contain food, called acid reflux. Patients with duodenal ulcer disease may also have panostomia, which is a rapid gush of large amounts of watery saliva from the mouth, a sign of increased vagal nerve activity. 3, heartburn: that is, a burning sensation behind the sternum, is an extremely common symptom in patients with ulcer disease. It may occur as a result of irritation caused by reflux of acidic gastric juices into the esophagus or as a result of reflex esophageal spasm. Heartburn is sometimes accompanied by reflux of acidic gastric juices into the mouth. 4.Appetite and weight: In patients with duodenal ulcer disease, appetite is usually good and often weight is often increased due to frequent eating to relieve pain, however, weight can be lost when chronic duodenal obstruction occurs. 5, colonic symptoms: many patients with duodenal ulcer disease are accompanied by irritable bowel syndrome. These patients may present with constipation and left lower abdominal pain. The pain is persistent or colicky and is relieved after defecation. 6, anemia symptoms: duodenal ulcer disease patients sometimes suffer from anemia and weakness due to chronic blood loss from ulcers. The prevention of gastric and duodenal ulcers should pay attention to the regularity of life, so that patients have enough sleep, rest, and should usually pay attention to the combination of work and rest. In addition to paying attention to the regulation of diet, develop good eating habits, using the principle of “small amount of meals, gradually increase”, eat more light, soft and easy to digest food and vitamin-rich fruits and vegetables, tobacco, alcohol, strong tea, coffee, acid, spicy, cold, fried and other foods should be avoided or taboo. Participate in physical exercise to enhance physical fitness. If the symptoms worsen, if there is bleeding in the stool (tar-like) or suspected bleeding (positive occult blood test), you should rest in bed. Avoid constipation by having regular bowel movements to maintain normal gastrointestinal function. Keep alkaline medicine in your home medicine cabinet. In case of stomach pain, antispasmodic and analgesic drugs can be applied. When taking care of the patient, close observation should be made, and the nature and duration of stomach pain, the relationship with food intake, and the effect of medication should be recorded. If you find that the patient has lost appetite and weight, you should go to the hospital for further examination to prevent the possibility of malignant changes (the main complications of this disease are hemorrhage, perforation, pyloric obstruction and carcinoma, etc.).