1. The pharmacopoeia prescribed extreme dose of 900mg/d; 2. 84.2% of patients develop clinical symptoms within 4h; dizziness, nausea, vomiting, convulsions; 3. Large amount of oral propafenone can cause many types of arrhythmias: (1) escape rhythm; (2) multi-level conduction block; (3) ventricular arrhythmias; Zhao Yong, Arrhythmia Diagnostic Center, Guangdong Provincial Hospital of Traditional Chinese Medicine; 3. The key to successful treatment: ( (1) continuous monitoring; (2) active removal of gastrointestinal toxins; (3) efforts to maintain stable heart rate and blood pressure; (4) active cardiopulmonary resuscitation. In the vast majority of patients, arrhythmias, shock, respiratory failure and impaired consciousness will be significantly reduced or disappeared after 24 hours of drug administration.4. Conventional blood purification measures cannot increase the clearance of propafenone.