At present, there is no best way to treat scleroderma, scleroderma treatment is based on the type of drug therapy and other treatments, common types of limited and systemic, the specific efficacy varies from person to person. 1. Limited scleroderma: Early limited scleroderma can be treated with topical glucocorticoid drugs such as dexamethasone. Prednisone and other hormones can also be injected into the skin lesions. If the linear scleroderma and cross joints, also need to pay attention to the joints of the activities of the situation, may be appropriate to apply massage and other physical therapy for treatment. 2. Systemic scleroderma (1) General treatment: avoid emotional fluctuations, especially excessive tension. At the same time, pay attention to keep warm, quit smoking, avoid trauma. (2) Drug treatment: often apply nifedipine, tolazoline and so on for anti-vascular spasm treatment; apply cyclosporine, cyclophosphamide, azathioprine, methotrexate and other immunosuppressants for anti-sclerosis treatment and so on. When the disease progresses faster and the inflammatory damage is obvious, glucocorticoid drugs such as prednisone can be used for treatment. The use of specific drugs should be under the guidance of a doctor. It is recommended that patients seek timely medical treatment and follow the doctor’s instructions to standardize treatment.