The corpus callosum is located at the base of the longitudinal fissure of the brain and consists of fibers that unite the neocortex of both cerebral hemispheres. Most of human’s neurological, emotional and cognitive activities require the communication and integration of both hemispheres, such as learning, memory, sensory, coordination and other functions that both hemispheres participate in together, so damage to the corpus callosum will cause symptoms of disconnection of the corresponding hemispheres. Cranial contusions rarely involve the deep white matter joint fibers of the hemispheres alone, while the corpus callosum is located at the base of the longitudinal fissure of the brain, adjacent to the top of the lateral ventricles, so the incidence of corpus callosum injury is extremely low, and isolated corpus callosum injury is even rarer. The disease is often accompanied by lesions in other parts of the brain. Five cases in this group were combined with multiple small intracerebral contusions, small intracerebral hematomas, and subarachnoid hemorrhage. The disease occurs mostly in traffic injuries, probably due to shear stress caused by rotational, twisting, and accelerating sexual violence of high-speed motion or sudden decelerating sexual violence to the head, resulting in injury to the nerve axons in the joint structures of the white matter between the two cerebral hemispheres. Injury to the corpus callosum is common in the body and pressure, which may be related to the direct force on the occipital part of the head in traffic injuries and the fact that the corpus callosum is thicker and has a relatively large anterior and posterior diameter, which is subjected to a stronger impact of violent waves. The front of the corpus callosum is connected to the end plate at the mouth, which is hidden and narrow, and is generally not easily damaged. The clinical symptoms and signs of corpus callosum injury are closely related to its pathological characteristics and the degree of combined brain injury. According to the different connection fibers, each part of the corpus callosum injury can appear corresponding clinical manifestations: the knee is connected to the frontal lobe, so the knee injury can appear mental symptoms, such as drowsiness, restlessness, excessive speech or change in temperament; the body and the two sides of the lobes have fiber connection, its injury can be manifested as aphasia, facial muscle paralysis, indifferent expression, etc.; the pressure part is connected to the occipital lobe, adjacent to the superior colliculus of the midbrain, may be related to visual conduction Therefore, most of the patients with pressure injury have visual impairment, with isotropic hemianopia being more common. It is worth noting that this lesion can sometimes show pupillary abnormalities, which should be distinguished from brain herniation, probably due to injury to the corpus callosum, compression of the anterior region of the midbrain parietal cap or hemorrhagic stimulation of the pupil on the side of the lesion. Injury to the pressure may also result in bilateral lower extremity dysfunction, aphasia, and dyslexia. Extensive injury to the corpus callosum is more symptomatic, lacking localized signs of corpus callosum lesions, and may have varying degrees of emotional abnormalities, personality changes, and movement disorders, but are often masked by the manifestations of concomitant other parts of the brain injury. In this group of 6 patients, there were different degrees of consciousness impairment, 3 cases of aphasia, 2 cases of bilateral pupil inequality, 2 cases of visual acuity loss, 3 cases of hemiparesis, 3 cases of positive cone bundle sign, 2 cases of memory loss and amnesia after injury. Since the corpus callosum injury was mostly non-hemorrhagic, the sensitivity of MRI diagnosis was better than CT, and T2W1 was the best display. In this group of 6 patients, all of them underwent cranial CT examination after admission and were found to have multiple small contusion lesions in the brain, combined with small intracerebral hematoma and subarachnoid hemorrhage in 5 cases, but no significant abnormalities in the morphology and density of the corpus callosum area were seen. 1 case showed no abnormalities in the morphology and density of the whole brain tissue by cranial CT. MRI is the best imaging tool to date to show non-hemorrhagic lesions in the corpus callosum. MRI is the best imaging tool to date to show non-hemorrhagic lesions of the corpus callosum, and it is not only sensitive to small intracranial lesions, but also can show lesions in multiple directions. In our opinion, when clinical symptoms are found to be inconsistent with the imaging performance, especially if the patient has no abnormalities in the cranial CT examination but has impaired consciousness, the possibility of corpus callosum injury should be considered and further MRI examinations should be performed in a timely manner to avoid missing the diagnosis. The blood supply to the corpus callosum originates from the short peri-callosal arteries of the anterior cerebral arteries on both sides, and its unique blood supply characteristics make it less susceptible to ischemia and reduced perfusion. All cases in this group were treated with appropriate amount of dehydration, lowering cranial pressure, nourishing brain cells, maintaining acid-base and water-electrolyte balance, etc. After the condition was stabilized, rehabilitation treatment such as hyperbaric oxygen was performed. All patients recovered consciousness, and only 2 cases had mild limb dysfunction. 1 month later, all patients were able to take care of themselves, and 3 patients showed the disappearance of corpus callosum lesion on cranial MRI after 1 month.