First of all, male infertility brings a heavy psychological burden to the patient, and attention should be paid to helping the patient to relieve psychological pressure and establish confidence in curing the disease during the treatment process. If you are depressed and anxious for a long time, you can cause endocrine disorders in the patient, leading to abnormal sperm production in the testicles, further weakening his fertility and making the treatment effect much less effective. The positive emotions can have a positive effect on the recovery of the disease. Secondly, male infertility patients should pay attention to the diet not to be partial, strengthen nutrition, appropriate more milk, egg yolk, lean meat, fish roe and other foods rich in high quality protein, more fresh vegetables, fruits, appropriate amount of vitamins and trace elements. Take care to avoid raw cottonseed oil, which is harmful to male fertility. Special emphasis is placed on the important role of smoking and alcohol cessation in the treatment of male infertility because nicotine in cigarettes has been shown to be a co-oxidant that impairs male fertility by inducing membrane damage, interfering with the reduced glutathione metabolic cycle, altering sperm morphology and survival, and inducing DNA breakage; alcohol consumption has a negative effect on the hypothalamic-pituitary Alcohol consumption has toxic effects on the hypothalamic-pituitary axis, testes and spermatozoa. Patients are also advised not to wear tight underwear or take sauna baths. Other physical and chemical factors such as radiation, radiotherapy and chemotherapy, electromagnetic radiation, heavy metals (e.g. lead, mercury, cadmium, etc.), and organochlorine compounds (e.g. dioxin, bicyclofuran, polychlorinated biphenyls, etc.) have adverse effects on male fertility and should be protected and avoided. It should also be noted that there are many drugs in clinical use that have adverse effects on male fertility. For example, some antihypertensive drugs affect male fertility by affecting sexual function; hormonal drugs can cause dysfunction of the hypothalamic-pituitary-gonadal axis, affecting its regulation of testicular spermatogenesis and leading to male infertility; some can affect the production, maturation and movement of sperm, such as adriamycin, vincristine and other chemotherapy drugs; some antibiotics such as Neomycin, gentamicin, erythromycin, etc. and H2 receptor blocker cimetidine can lead to a decrease in semen quality; immunosuppressants such as cyclosporine can cause a decrease in sperm density and viability; and the Chinese herbal medicine Leigongtang preparation also has anti-fertility effects. The adverse effects of these drugs on fertility should be noted when patients need to use them for their illness. Since the growth cycle of male sperm is about 74d, the treatment of male infertility should be based on 3 months of continuous treatment as a course of treatment, and generally 3 courses of treatment are needed to evaluate the efficacy. Many patients are anxious to ask why they do not see their wives pregnant after 1-2 months of treatment, and have doubts about the effect of treatment or even lose confidence as a result, which is not conducive to the recovery of the patient, so care should be taken to carefully explain to the patient and his spouse. Finally, the important role of close cooperation between the couple in the process of male infertility treatment is emphasized. The woman should be sympathetic and concerned about the male partner’s fertility problems, and should never be left out of the equation. The wife’s tenderness and consideration should be used to harmonize the couple’s feelings and close their relationship, thus helping to enhance the patient’s confidence and promote the recovery of the patient’s fertility. And guide the couple to maintain a moderate frequency of sexual life, generally 1 to 2 times a week is appropriate, with special attention to the female partner’s ovulation intercourse to improve the chances of conception. In this way, it will not be long before the infertile couple’s good wish to have the next generation is realized.