Recently, Hangzhou Cancer Hospital (Hangzhou First People’s Hospital Wushan Hospital District) Cancer Chemotherapy Center admitted a patient Wu Ying (a pseudonym) whose right leg was amputated due to a dense soybean-sized mass, which was diagnosed as a rare soft tissue sarcoma after examination. Wu Ying is 69 years old, a native of Hangzhou, who usually pays attention to physical exercise and has always been in good health. Half a year ago due to rheumatoid arthritis attack, when doing leg massage found a soybean-sized particles in the inner side of the right calf, no pain, no itch, did not care about it, after two weeks found that the growth of three, to the hospital, but did not find out what. Wu Ying has been uneasy, accompanied by family members to the Shanghai Hospital for examination, did lumpectomy, diagnosed as hemangiomatosis by biopsy. A month later, the right side of the calf excision part of a circle and grew several soybean-sized lumps. “Usually live and eat regularly, and did not have a disease, how will grow a tumor?” Wu Ying is still puzzled. So the family rushed to Beijing Hospital for examination. Another lumpectomy was done, and this time the biopsy diagnosed a low-grade malignant vascular endothelial tumor. Without any treatment, Wu Ying’s family returned to Shanghai. Two months later, Wu Ying’s right leg mass recurred again, this time the mass spread to the thigh, densely packed a large soybean-sized mass, did a PET-CT examination, the results found that the tumor local recurrence. After consulting with many hospitals, they all suggested amputation surgery. Watching the right leg lumps grow more and more, Wu Ying finally had to amputation. The final pathological diagnosis is mucinous fibrosarcoma. “I didn’t expect a lump the size of a soybean to be so powerful.” Lying on the hospital bed, Wu Dabo mumbled. Yesterday, Wu Dabo has started the first chemotherapy. According to Zheng Song, deputy chief physician of Oncology Chemotherapy Center, malignant soft tissue tumors of the limbs are usually called soft tissue sarcoma, and clinically, liposarcoma, malignant fibrous histiocytoma, synovial sarcoma, fibrosarcoma, smooth muscle sarcoma, rhabdomyosarcoma are more common. Thigh is the most common site of soft tissue sarcoma. Due to the abundance of soft tissues such as thigh muscle and fat, soft tissue tumors deep in the thigh are not easy to be detected in the early stage, and the symptoms are not obvious, and most of them are diagnosed when the tumor is large in size. Most of the soft tissue sarcomas recur repeatedly due to incomplete surgery and irregular treatment, resulting in wider and wider lesions, forming huge soft tissue sarcomas, and ultimately amputation has to be performed. Surgery alone cannot solve the problems of postoperative recurrence and distant metastasis. Surgical resection plus radiotherapy, chemotherapy and other comprehensive treatments should be adopted for soft tissue sarcoma, which can effectively reduce the local recurrence rate. Targeted therapy can also be used for patients with recurrence or advanced stage. However, for large tumors with short course, rapid development and high malignancy, high-dose chemotherapy should be done before and after surgery to prevent distant metastasis and create conditions for limb-sparing surgery. Zheng Song, deputy chief physician, reminded that cancer development has a process, usually the public found uncomfortable symptoms or limbs with unexplained lumps, to go to the hospital as soon as possible to check, do not procrastinate.